Fibrinogen is a soluble glycoprotein and a clotting factor (factor I) which is an essential component for clotting present in plasma. This plays an important role in the breaking down of fibrinogen to fibrin by the enzymatic action of thrombin. Inherited fibrinogen disorders can be divided into two types i.e. afibrinogenemia and hypofibrinogenemia. This condition can be fatal if not managed properly by the Ayurvedic medicine system.
What is Afibrinogenemia?
Afibrinogenemia is a rare coagulation disorder which is also referred to as congenital afibrinogenemia which is usually inherited as an autosomal recessive trait. This condition is generally characterized by the virtual absence of plasma immune-reactive fibrinogen (Factor I) which can be measured by antigenic or functional assays. The prevalence of this disease is estimated in one to 1,000,000 and male or females, both can get equally affected. (1)
What are the Possible Causes of Afibrinogenemia?
Thereare two factors which can trigger this condition -1. Mutation Afibrinogenemia
It is generally caused by fibrinogen deficiency in plasma which is triggered by homozygous or heterozygous mutations; affecting any of the three fibrinogen genes i.e. FGA, FGB, and FGG). This mutation results in the partial or complete absence of fibrinogen. Each gene is responsible for making a part or subunit of protein.
2. Inheritance Afibrinogenemia
The parent of an affected infant with an autosomal recessive condition carries one copy of the mutated gene. These individuals are termed carriers and have abnormal levels of fibrinogen in the blood. (2)
How to Recognize Afibrinogenemia?
The fibrinogen levels below 0.1 g/L; represents bleeding abnormalities which may range from mild to severe. It was studied that if bleeding occurs from the umbilical cord just after pregnancy; this can be an early alert to afibrinogenemia.
Some of the other Symptoms Include
- Nose bleeding which can be difficult to stop (Epistaxis)
- Bleeding in the mucous membrane
- Gastrointestinal bleeding
- Postpartum hemorrhage and menorrhagia
- Heavy bleeding after injury
- Spleen rupture
- Intracranial hemorrhage (rare)
- Miscarriage
- Prolonged menstruation in females
- Swelling and inflammation in joints
- Bleeding gums (Gingival bleeding) (3)
How Afibrinogenemia Can be Diagnosed?
Doctors usually look at a person's medical history, physical examination and certain laboratory assays are performed for the confirmation. A person with afibrinogenemia the results are based on the fibrin which is a product of fibrinogen. The tests include Thrombin time (TT), Prothrombin time (PTT), Reptilase time and activated partial thromboplastin time (aPTT).
Beneficial Ayurvedic Herbs in Afibrinogenemia
This traditional herb is beneficial in pacifying Kapha dosha and balancing Pitta dosha. Lodhra works effectively in bleeding disorders and is considered an amazing coagulant which reduces bleeding and effectively healing wounds.
Ashoka is very helpful in controlling internal bleeding and hemorrhagic bleeding.
3. Lotus
Lotus which is commonly known as Kamal kakdi has astringent properties so it is a proven natural remedy for bleeding disorders.
4. Priyangu
Priyangu ( Callicarpa macrophylla) can effectively decrease the clotting time of blood.
Ayurvedic Aspect of Afibrinogenemia
According to Ayurvedic principles, afibrinogenemia is considered as sejvikaras or congenital which gets triggered when there is one or more raktadhatu is absent. This ultimately results in interference to raktastambhak action of blood.
Ayurvedic Treatment for Afibrinogenemia by Planet Ayurveda
For Afibrinogenemia, Planet Ayurveda is offering 100% pure, natural and vegetarian herbal formulations which have been manufactured under the strict supervision of MD Ayurveda experts. Some of the herbal products include Pitta balance capsules, Cloto plan syrup, Kamdudha ras, and Mukta panchamrit ras. All these medicines will not result in any kind of side effects.
1. Pitta Balance Capsules
Pitta balance capsules are amazing herbal formulation by Planet Ayurveda which includes Mukta Pishti (Mukta Pishti) and Giloy ( Tinospora cordifolia), Praval Pishti (Coral calcium), Akik pishti (Agate calcium), Jahar Mohra Pishti (Calcium compound) and Kamdudha Ras (Calcium compound). These herbs in combination effectively enhance healthy digestion and metabolism. Giloy is the combination that helps in enhancing immunity, detoxification of the blood and flushing out toxins out of the body. Akik Pishti and Parval Pishti are beneficial in balancing Vata and Pitta Dosha.
Dosage - 1-2 capsules two times a day with plain water after meals.
2. Cloto Plan Syrup
This herbal syrup contains standardized extracts of Jhandu ( Tagetes erecta), Priyangu ( Callicarpa macrophylla), Doorva ( Cynodon dactylon), Dhataki ( Woodfordia fruticosa) and Sheesham leaves ( Dalbergia sissoo). Sheesham leaves and Priyangu works tremendously in faster healing and decreasing clotting time of blood. Jhandu and Doorva help in blood purification and all aliments related to vitiation of blood or Rakta. Dhataki has done wonders in relieving inflammation and possess great healing qualities.
Dosage - 1-2 teaspoon two times a day
3. Kamdudha Ras Tablets
Kamdudha Ras is a classical Ayurvedic formulation containing medicinally important herbs like Amrutha Satva or Giloy ( Tinospora cordifolia), Swarna gairika, Praval pishti, Mukta pishti, Shankh bhasma, Shukti bhasma and Kapardak bhasma. Giloy (Guduchi) possesses anti-inflammatory, anti-bacterial, hepatoprotective and healing properties. Swarna gairika is considered as Pitta-Nashak (destroys Pitta dosha), Balya (Provides strength) and Kapha-hara (Pacify kapha dosha). Praval pishti and Mukta pishti are cooling agents that are beneficial in balancing vitiated Pitta and Rakta dosha. Shukti bhasma works effectively in treating various digestive ailments like gastritis, indigestion, etc.
Dosage - 1-2 tablets two times a day with plain water after meals.
Mukta Panchamrit Ras is a classical preparation from Planet Ayurveda in tablet form containing metal ingredients. This formulation comprises of Mukta Bhasma (Pearl bhasma), Pravala bhasma (Coral bhasma), Vanga bhasma, Shankha bhasma (Conch shell bhasma), Shukti bhasma (Pearl Oyster bhasma), Shukti bhasma (Pearl oyster bhasma), Ikshurasa (Sugarcane juice), Godudghda (Cow's milk) and juice extracts of Vidari ( Pueraria tuberosa), Ghrit Kumari (Aloe vera), Shatavari ( Asparagus racemosus), Tulsi ( Ocimum sanctum) and Hamsapadi ( Adiantum philippense). Mukta Panchamrit Ras has proved to be beneficial in managing various ailments related bleeding disorders.
Dosage250 mg 1-2 times a day before or after meals. It can be taken with honey, milk or Luke warm water.
Conclusion
In order to conclude with this information, it is crystal clear that this rare bleeding disorder can get managed naturally with Ayurvedic herbs and herbal supplements from Planet Ayurveda.
References
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956798/
- https://pubmed.ncbi.nlm.nih.gov/27164460-congenital-afibrinogenemia-identification-and-characterization-of-two-novel-homozygous-fibrinogen-a-and-b-chain-mutations-in-two-tunisian-families/
- https://rarediseases.info.nih.gov/diseases/5761/afibrinogenemia
