Abstract
In 1933, Dawson described an entity he termed "inclusion body encephalitis," which was characterized by subacute encephalitis, loss of nerve cells, and Cowdry A inclusion bodies in neurons and glial cells. Van Bogaert (1945) reported a clinically similar disease in which the white matter of the brain showed intense fibrillary gliosis associated with a variable subacute inflammatory infiltrate, which he called "subacute sclerosing leukoencephalitis". Later, inclusion bodies were found in Van Bogaert's cases. It is now clear that both authors were describing the same disease, and further, that the disease is related to infection by the measles virus. The disease is now designated as subacute sclerosing panencephalitis. So, today we will read about SSPE in this article in brief.
Introduction
It is a condition of progressive neurological related disorder which affects mainly the central nervous system of the brain that leads to inflammation of the brain. The disease generally attacks children, although it can sometimes be seen in adolescents and young adults. The onset is heralded by personality changes, followed by involuntary movements.
Causes and Pathogenesis
It is caused by measles infection and disease diagnosed after many years of measles infection. The precise pathogenesis of SSPE is unclear, but several pieces of evidence suggest that lysis of neurons or oligodendroglia is induced not by direct action of the virus, but rather by antibody or cell mediated reactions directed against viral infected cells.
Symptoms
- Poor school performance
- Hallucination
- Insomnia
- Inflammation in brain
- Distract easily
- Motor function disturbed
- Temper outburst
- Suddenly muscular jerks of head, arms or other body part may occur
- Behavioral changes
- Intellectual problem
- Forgetfulness
- Ataxia
- Later, muscle rigidity increase and difficulty in swallowing
Diagnosis
On gross examination
The brain may be normal or firm and may contain regions of granularity and focal destruction.
On microscopic examination
There is a perivascular mononuclear cell infiltrate as well as Cowdry A inclusion bodies in neurons or oligodendroglia. Such inclusions have been shown to contain viral particles by electron microscopy. Neuronophagia and extensive neuronal loss are present in severely involved regions. Dense fibrillary gliosis follows as the process becomes older.
EEG
The EEG exhibits characteristic bursts of high-voltage activity. In most cases, the disease progresses relentlessly and devastates the brain, often leading to death.
CSF (cerebrospinal fluid)
An elevation of IgG is present in CSF, with an oligoclonal pattern and high levels of measles antibodies are present in the CSF of such patients.
Fluorescent antibody test
Measles antigen has been found in the neurons and glial cells of patients with SSPE by the direct fluorescent antibody test
Brain biopsy
Measles virus has also been cultured from the brain biopsy tissue of several cases of SSPE. It appears that the measles virus is present in the brain as an incomplete virus with defective replication.
Treatment
Subacute sclerosing panencephalitis has no treatment or cure available at present. If it is diagnosed in stage 1 then it may be possible to manage the condition by intraventricular interferon alfa and oral isoprinosine, but the effect of these medications vary from patient to patient. Only supportive treatment is given in this disease.
Ayurvedic overview
In Ayurveda, we can correlate SSPE with two main factors, one of the factors is vitiation of tridosha that is vata, pitta and kapha along with pranvaha srotas dusti and another is aagantuj vyadhi because it is caused by measles virus. Vitiation of vata takes place from either wasting of dhatus or obstruction in passage. Vata, pitta and kapha move in all the channels of the body. Due to subtleness, vata itself provokes the other two doshas that are pitta and kapha. When aggravated it excites them and carrying them to different places produces different disorders due to obstruction in passage and dries up rasa etc. This produces symptoms of all three doshas in this disease.
Herbal remedies for SSPE by planet ayurveda
Planet Ayurveda provides different kinds of ayurvedic medicines for various kinds of diseases in which effective and natural herbs are used. They strictly follow all the principles of ayurveda which are described in ancient textbooks of ayurveda. All these medicines are GMP certified and vegetarian. These are safe to use and effective in the human body. There are no preservatives, chemicals, yeast etc. In this disease, no treatment is available at present. Only supportive treatment will be given. These herbal remedies can be considered for treatment of this disease until stage 2. These medicines will lead to delayed progression of this disease. The planet ayurveda provides herbal remedies for subacute sclerosing panencephalitis which are following
Product List
- Gandhak rasayan
- Neurogenie capsules
- Boswellia + Curcumin
- Gotu kola capsules
- Indian valeriana
PRODUCT DESCRIPTION
1. Gandhak rasayan
It is a herbal tablet made from shuddha gandhak (purified sulphur). It is an antimicrobial, antibacterial, antipyretic, anti-allergic, anti-inflammatory antiviral and a broad spectrum antibiotic. It kills intestinal worms and is a good blood purifier. It contains various antioxidants. It is an immunity booster and indicated in infertility, debility, indigestion, breathlessness, abdominal pain. It detoxifies the blood, impurities, clears dirt and prevents secondary infection. It is very useful in urinary tract infection along with expelling the harmful pathogen from the body system.
DOSE:- 2 Tablet twice daily with lukewarm water
2. Neurogenie capsules
It is a polyherbal capsule made from brahmi (bacopa monnieri), ashwagandha (withania somnifera). It is bitter and astringent in taste and light and slightly hot in effect. It is a pacifier of all the three doshas (vata, pitta and kapha). It has a tonic effect on the brain and the nervous system. It possesses antioxidant properties, and also has the amazing ability to facilitate learning and enhance memory and concentration. It is a medicine that braces the mind to carry cognitive functions and intellectual pursuits. It is beneficial for maintaining all the three doshas, it counteracts the vitiated vata dosha-the factors which govern the nervous system. It is very good medicine for reducing the effects of stress and nervous anxiety.
DOSE:- 2 Capsules twice daily with plain water, after meals
3. Boswellia+Curcumin
It is a polyherbal capsule made from shallaki (Boswellia serrata) and haridra (curcuma longa). It is bitter and pungent in taste and dry, light and hot in effect. It alleviates kapha and vata. It has anti-inflammatory features which stops the cytokines secretion and reduces inflammation or swelling. It has an antioxidant property which protects brain neurons and reduces the wrinkles on skin. It purifies the blood and helps in blood formation in the body. It is used in various diseases like acne, blemishes, burns, auto-immune disorders and liver diseases. It also applies on cuts and bruises because it is a natural antibiotic. It prevents colon and skin tumors. It is known as antibacterial, anti-allergic, carminative and diuretic medicine. It is an effective remedy for sprains, wounds and inflamed joints.
DOSE:- 1 capsule twice daily, after meals with plain water.
4. Gotu kola capsules
It is a single herbal capsule containing gotu kola (centella asiatica). It is bitter and astringent in taste. It is light and mildly hot in effect. It has the ability to enhance memory and learning power. It is a tranquiliser, a muscle relaxant, an anticonvulsant, a blood purifier, an antipyretic, carminative and digestive agent. It balances all the three doshas-vata, pitta and kapha. It is useful in anxiety, depression, hypertension, sleeplessness, mental retardation, insanity and hysteria. It also helps maintain clarity of thoughts and is effective in age related mental disorders in old persons. It is indicated in anxiety, depression and nervous exhaustion.
DOSE:- 2 Capsules twice daily with plain water, after meals.
5. Indian valeriana
It is a single herbal capsule made from tagar (valeriana wallichii). It is pungent, bitter and astringent in taste. It is light, slimy and hot in effect. It balances all the three doshas- mainly vitiated kapha and vata dosha. It is a wound healer. It is indicated in indigestion, abdominal pain, enlargement of liver, arthritis, general debility, convulsion, hysteria, skin disease, fever, etc. It is a soothing and sedative action on the central nervous system. It is very effective in restlessness, palpitations and mild hypertension. Due to its sedative action it is very effective in chronic anxiety, depression, insomnia, migraine, and tension headaches.
DOSE:- 1 Capsule twice daily with plain water, after meals.
Contact Planet Ayurveda Support Team to provide you the costing / ordering and delivery information at - [email protected] or Call at 0172-521-4030 (India), +91-172-521-4030 (Outside India) or Whatsapp at (+91) 9915-593-604Conclusion
Subacute sclerosing panencephalitis is the neurological condition in which inflammation of the brain takes place. In ayurveda, we can correlate this disease with imbalance of tridosha that is vata, pitta and kapha and another reason is aagantuj vyadhi because it is caused by measles virus infection. There is no treatment as such for this disease but we can give supportive treatment to delay the progression of disease. We can use various kinds of herbs like shuddha gandhak, brahmi, ashwagandha, boswellia, curcumin, gotu kola etc which are very effective in inflammatory conditions as well as soothing the mind and enhancing the intellectual power. . Herbal medicines like gandhak rasayan, neurogenie capsules, indian valeriana etc are wonderful medicines for the management of SSPE until stage 2.
DR. Vikram Chauhan, MD - AYURVEDA is an expert ayurvedic doctor based in Chandigarh, India and doing his practice in Mohali, India. He is spreading the knowledge of Ayurveda - Ancient healing treatment, not only in India but also abroad. He is the CEO and Founder of Planet Ayurveda Products, Planet Ayurveda Clinic and Krishna Herbal Company. Write at - [email protected], Contact at - +91-172-521-4030 Websites - www.planetayurveda.com, www.alwaysayurveda.com
View more posts from this authorAbstract
In 1933, Dawson described an entity he termed "inclusion body encephalitis," which was characterized by subacute encephalitis, loss of nerve cells, and Cowdry A inclusion bodies in neurons and glial cells. Van Bogaert (1945) reported a clinically similar disease in which the white matter of the brain showed intense fibrillary gliosis associated with a variable subacute inflammatory infiltrate, which he called "subacute sclerosing leukoencephalitis". Later, inclusion bodies were found in Van Bogaert's cases. It is now clear that both authors were describing the same disease, and further, that the disease is related to infection by the measles virus. The disease is now designated as subacute sclerosing panencephalitis. So, today we will read about SSPE in this article in brief.
Introduction
It is a condition of progressive neurological related disorder which affects mainly the central nervous system of the brain that leads to inflammation of the brain. The disease generally attacks children, although it can sometimes be seen in adolescents and young adults. The onset is heralded by personality changes, followed by involuntary movements.
Causes and Pathogenesis
It is caused by measles infection and disease diagnosed after many years of measles infection. The precise pathogenesis of SSPE is unclear, but several pieces of evidence suggest that lysis of neurons or oligodendroglia is induced not by direct action of the virus, but rather by antibody or cell mediated reactions directed against viral infected cells.
Symptoms
- Poor school performance
- Hallucination
- Insomnia
- Inflammation in brain
- Distract easily
- Motor function disturbed
- Temper outburst
- Suddenly muscular jerks of head, arms or other body part may occur
- Behavioral changes
- Intellectual problem
- Forgetfulness
- Ataxia
- Later, muscle rigidity increase and difficulty in swallowing
Diagnosis
On gross examination
The brain may be normal or firm and may contain regions of granularity and focal destruction.
On microscopic examination
There is a perivascular mononuclear cell infiltrate as well as Cowdry A inclusion bodies in neurons or oligodendroglia. Such inclusions have been shown to contain viral particles by electron microscopy. Neuronophagia and extensive neuronal loss are present in severely involved regions. Dense fibrillary gliosis follows as the process becomes older.
EEG
The EEG exhibits characteristic bursts of high-voltage activity. In most cases, the disease progresses relentlessly and devastates the brain, often leading to death.
CSF (cerebrospinal fluid)
An elevation of IgG is present in CSF, with an oligoclonal pattern and high levels of measles antibodies are present in the CSF of such patients.
Fluorescent antibody test
Measles antigen has been found in the neurons and glial cells of patients with SSPE by the direct fluorescent antibody test
Brain biopsy
Measles virus has also been cultured from the brain biopsy tissue of several cases of SSPE. It appears that the measles virus is present in the brain as an incomplete virus with defective replication.
Treatment
Subacute sclerosing panencephalitis has no treatment or cure available at present. If it is diagnosed in stage 1 then it may be possible to manage the condition by intraventricular interferon alfa and oral isoprinosine, but the effect of these medications vary from patient to patient. Only supportive treatment is given in this disease.
Ayurvedic overview
In Ayurveda, we can correlate SSPE with two main factors, one of the factors is vitiation of tridosha that is vata, pitta and kapha along with pranvaha srotas dusti and another is aagantuj vyadhi because it is caused by measles virus. Vitiation of vata takes place from either wasting of dhatus or obstruction in passage. Vata, pitta and kapha move in all the channels of the body. Due to subtleness, vata itself provokes the other two doshas that are pitta and kapha. When aggravated it excites them and carrying them to different places produces different disorders due to obstruction in passage and dries up rasa etc. This produces symptoms of all three doshas in this disease.
Herbal remedies for SSPE by planet ayurveda
Planet Ayurveda provides different kinds of ayurvedic medicines for various kinds of diseases in which effective and natural herbs are used. They strictly follow all the principles of ayurveda which are described in ancient textbooks of ayurveda. All these medicines are GMP certified and vegetarian. These are safe to use and effective in the human body. There are no preservatives, chemicals, yeast etc. In this disease, no treatment is available at present. Only supportive treatment will be given. These herbal remedies can be considered for treatment of this disease until stage 2. These medicines will lead to delayed progression of this disease. The planet ayurveda provides herbal remedies for subacute sclerosing panencephalitis which are following
Product List
- Gandhak rasayan
- Neurogenie capsules
- Boswellia + Curcumin
- Gotu kola capsules
- Indian valeriana
PRODUCT DESCRIPTION
1. Gandhak rasayan
It is a herbal tablet made from shuddha gandhak (purified sulphur). It is an antimicrobial, antibacterial, antipyretic, anti-allergic, anti-inflammatory antiviral and a broad spectrum antibiotic. It kills intestinal worms and is a good blood purifier. It contains various antioxidants. It is an immunity booster and indicated in infertility, debility, indigestion, breathlessness, abdominal pain. It detoxifies the blood, impurities, clears dirt and prevents secondary infection. It is very useful in urinary tract infection along with expelling the harmful pathogen from the body system.
DOSE:- 2 Tablet twice daily with lukewarm water
2. Neurogenie capsules
It is a polyherbal capsule made from brahmi (bacopa monnieri), ashwagandha (withania somnifera). It is bitter and astringent in taste and light and slightly hot in effect. It is a pacifier of all the three doshas (vata, pitta and kapha). It has a tonic effect on the brain and the nervous system. It possesses antioxidant properties, and also has the amazing ability to facilitate learning and enhance memory and concentration. It is a medicine that braces the mind to carry cognitive functions and intellectual pursuits. It is beneficial for maintaining all the three doshas, it counteracts the vitiated vata dosha-the factors which govern the nervous system. It is very good medicine for reducing the effects of stress and nervous anxiety.
DOSE:- 2 Capsules twice daily with plain water, after meals
3. Boswellia+Curcumin
It is a polyherbal capsule made from shallaki (Boswellia serrata) and haridra (curcuma longa). It is bitter and pungent in taste and dry, light and hot in effect. It alleviates kapha and vata. It has anti-inflammatory features which stops the cytokines secretion and reduces inflammation or swelling. It has an antioxidant property which protects brain neurons and reduces the wrinkles on skin. It purifies the blood and helps in blood formation in the body. It is used in various diseases like acne, blemishes, burns, auto-immune disorders and liver diseases. It also applies on cuts and bruises because it is a natural antibiotic. It prevents colon and skin tumors. It is known as antibacterial, anti-allergic, carminative and diuretic medicine. It is an effective remedy for sprains, wounds and inflamed joints.
DOSE:- 1 capsule twice daily, after meals with plain water.
4. Gotu kola capsules
It is a single herbal capsule containing gotu kola (centella asiatica). It is bitter and astringent in taste. It is light and mildly hot in effect. It has the ability to enhance memory and learning power. It is a tranquiliser, a muscle relaxant, an anticonvulsant, a blood purifier, an antipyretic, carminative and digestive agent. It balances all the three doshas-vata, pitta and kapha. It is useful in anxiety, depression, hypertension, sleeplessness, mental retardation, insanity and hysteria. It also helps maintain clarity of thoughts and is effective in age related mental disorders in old persons. It is indicated in anxiety, depression and nervous exhaustion.
DOSE:- 2 Capsules twice daily with plain water, after meals.
5. Indian valeriana
It is a single herbal capsule made from tagar (valeriana wallichii). It is pungent, bitter and astringent in taste. It is light, slimy and hot in effect. It balances all the three doshas- mainly vitiated kapha and vata dosha. It is a wound healer. It is indicated in indigestion, abdominal pain, enlargement of liver, arthritis, general debility, convulsion, hysteria, skin disease, fever, etc. It is a soothing and sedative action on the central nervous system. It is very effective in restlessness, palpitations and mild hypertension. Due to its sedative action it is very effective in chronic anxiety, depression, insomnia, migraine, and tension headaches.
DOSE:- 1 Capsule twice daily with plain water, after meals.
Contact Planet Ayurveda Support Team to provide you the costing / ordering and delivery information at - [email protected] or Call at 0172-521-4030 (India), +91-172-521-4030 (Outside India) or Whatsapp at (+91) 9915-593-604Conclusion
Subacute sclerosing panencephalitis is the neurological condition in which inflammation of the brain takes place. In ayurveda, we can correlate this disease with imbalance of tridosha that is vata, pitta and kapha and another reason is aagantuj vyadhi because it is caused by measles virus infection. There is no treatment as such for this disease but we can give supportive treatment to delay the progression of disease. We can use various kinds of herbs like shuddha gandhak, brahmi, ashwagandha, boswellia, curcumin, gotu kola etc which are very effective in inflammatory conditions as well as soothing the mind and enhancing the intellectual power. . Herbal medicines like gandhak rasayan, neurogenie capsules, indian valeriana etc are wonderful medicines for the management of SSPE until stage 2.
