Abstract
Giardiasis is a protozoal infection. This disease affects our intestines. There are billions of bacteria in our intestines which are helpful to digest and absorb nutrients. But infectious bacteria or organisms cause infection in our gut. Giardiasis infection is caused by flagellate giardia intestinalis called giardia lamblia. This disease is spread through people to others. In this disease a person is having diarrhea, vomiting, abdominal cramps, bloating, loss of appetite, lethargy, abdominal tenderness and distension. The treatment of choice in Allopathy is tinidazole and metronidazole. So in this article we are going to discuss tinidazole and metronidazole along with effective Ayurvedic medicines in detail.
What is Tinidazole and Metronidazole?
These drugs come under the class of antiamoebic and antiprotozoal drugs. These drugs are useful in infection which is caused by a protozoa Entamoeba histolytica. These two drugs are the prototype of nitroimidazole which was introduced in 1959 for trichomoniasis. But later on it is found that it is a highly active amoebicide. Metronidazole and Tinidazole have broad-spectrum cidal activity against anaerobic protozoa. But they do not affect aerobic bacteria. They are selectively toxic to anaerobic and microaerophilic microorganisms. After entering into the bacterial cell by diffusion, the nitro radical of these drugs reduced the activity of the bacteria. This nitro radical exerts cytotoxicity (probably by damaging DNA). In addition metronidazole and tinidazole have been found to inhibit the cell mediated immunity which induce mutagenesis and thus further cause radio sensitization. These both drugs are used in intestinal as well as extra intestinal infections also.
Pharmacokinetics
Metronidazole and Tinidazole are almost completely absorbed from small intestines. Little unabsorbed drugs reach the colon. Metabolism occurs in the liver by oxidation and glucuronide conjugation. Plasma t1/2 of metronidazole is 8 hours.
Adverse effects
Adverse effects of these two drugs are relatively frequent and unpleasant. The side effects of these two drugs are
- Anorexia, Nausea, Metallic taste, abdominal cramps, loose stool are the most common side effects.
- Headache, glossitis, dryness of mouth, and dizziness are the less frequent side effects.
- Prolonged use of these drugs causes peripheral neuropathy and CNS effect.
Contraindications
It is contraindicated in the following- Neurological disease
- Blood dyscrasias
- First trimester of pregnancy
Uses of Metronidazole and Tinidazole
These are useful in- Amoebiasis
- Giardiasis
- Trichomonas vaginitis
- Anaerobic bacterial infections
- Helicobacter pylori gastritis
Dosage
- Metronidazole- 400 mg TDS
- Tinidazole- 0.6 gm
Difference between Metronidazole and Tinidazole
Tinidazole is mainly equally effective congener of metronidazole, but some little difference is there
- Its plasma t1/2 is 12 hour
- Duration of action is longer than metronidazole
- It is more suited in single dose
Because of the adverse effects of these medicines, we are introducing some safe and herbal products for the treatment of giardiasis
Herbal Products for Giardiasis
Planet Ayurveda offers the best herbal products for the treatment of giardiasis. This is a manufacturing company which manufactures various herbal products and these herbal products are made using the standardized extracts of potential herbs. Also these are made under expert advice.
- Sanjivani Vati
- Mahashankh Vati
- Wormistop Capsules
Product description
1. Sanjivani Vati
This is a classical Ayurvedic formulation. It is a natural source of life and health. this vati contains very potent herbs like- sonth (Zingiber officinale), harar (Terminalia chebula), bahera (Terminalia bellerica), amla (Emblica officinalis), vidanga (Embelia ribes), giloy ( cordifolia), shuddha Bhallataka (Purified Semecarpus anacardium) etc. It has antipyretic and diaphoretic properties. It is also known as the best Aama ( endotoxins) digestive. It also helps in maintaining the metabolism.
Dosage: 1 tablet twice a day after meals with plain water
2. Mahashankh Vati
This is also a classical ayurvedic medicine. This is a natural solution for abdominal pain, acidity and indigestion. This Ayurvedic formulation contains chitrak ( ), danti (Baliospermum montanum), sajjikshara ( natural sodium carbonate) etc. this herbal product of planet ayurveda is best for digestive disorders such as indigestion, abdominal pain, disturbed bowel movement, loss of appetite etc. It has anti-inflammatory and anti-helminthic properties.
Dosage: 1 tablet twice a day after meals with plain water
3. Wormistop Capsules
These are poly herbal formulations of Planet Ayurveda. This formulation is helpful in managing infectious diseases like giardiasis. These capsules are made using the standardized extracts of palaash (Butea monosperma), tulsi (Ocimum sanctum), vidanga (Embelia ribes), sonth (Zingiber officinale). These ingredients are very effective for treating digestive problems. It is helpful in alleviating the digestive symptoms like indigestion, bloating, pain, excessive hunger etc.
Dosage: 1 capsule twice a day after meals with plain water
Conclusion
As we saw that allopathic medicines have drastic side effects. They are helpful in treating giardiasis but left with side effects in the body. So it's better to take Ayurvedic medicines for better results. Moreover, these ayurvedic medicines are left with no side effects and treat the disease from its root cause. So one should use herbal products of Planet Ayurveda and enjoy a happy and healthy life.
