Champions Chelsea travel to Stoke City looking to bounce back from the goalless draw against Arsenal last weekend. The Blues are 3 points behind the two Manchester clubs and Antonio Conte will not want to give away a big lead even at this early stage in the season.
Stoke are in 13 th place with just one win so far. They are, however, the only team to take points off Manchester United this season, with a 2-2 draw at the Britannia Stadium two weeks ago.
Chelsea haven't been all that flattering at home, but have won 7 out of their last 8 league games away from home stretching back to last season. This year, they have won on each of their 3 visits.
Man to watch out for: Eden Hazard could be given his first start in the Premier League this season after playing against Nottingham Forest in the League Cup in midweek.
2) Swansea City vs Watford (September 23, 15:00 BST)Swansea will be looking to push on after earning a hard-fought goalless draw away at Spurs last week. Watford, on the other hand, will be looking for their third consecutive away of the season, and to bounce back after being thrashed by Man City last week.
The Swans are in 14 th, but haven't looked too shabby despite losing Fernando Llorente and Gylfi Sigurdsson in the summer. Paul Clement's men will look to games like this one as must-wins if they are survive in the top-flight this year.
Man to watch out for: Swansea striker Wilfried Bony could make his first start since re-joining from Man City in the summer.
Prediction: Swansea City 1-0 Watford 3) Leicester City vs Liverpool (23 September, 17:30 BST)In a repeat of the midweek League Cup encounter, Liverpool travel to the King Power Stadium to take on Leicester City. On Tuesday, it was the home side that came out on top by a 2-0 scoreline.
The Foxes have struggled in the league so far, winning just once and finding themselves in 15 th. Craig Shakespeare's men have shown promise, but have been unable to turn positive performances into positive results.
Liverpool, on the other hand, has struggled to put away teams just like they did last season. They had 35 shots on goal against Burnley last week, but the match somehow ended 1-1.
Man to watch out for: Philippe Coutinho could make his first start in the Premier League this season and could well be the difference between the two sides.
Prediction: Leicester City 2-2 Liverpool 4) Brighton & Hove Albion vs. Newcastle United (24 September, 16:00 BST)The Championship winners from last season play the Championship runners-up.
The sides' fortunes in the Premier League though, have been vastly different. Brighton have won just once and are struggling in 16 th place, while Newcastle are flying high in 4 th, following three consecutive victories.
Man to watch out for: Christian Atsu was one of Newcastle's best players last season, and has carried on his form into the Premier League as well.
Prediction: Brighton & Hove Albion 1-1 Newcastle United 5) Arsenal vs West Bromwich Albion (25 September, 20:00 BST)Arsene Wenger got some reprieve last week following a gutsy draw at Stamford Bridge. The Gunners though, are still in the bottom half in 12 th. They need to get back among the big boys pretty quickly, or will face the risk of missing out on the top 4 for the second season in a row.
Their opponents at the Emirates Stadium on Monday, West Brom, are two places above them. After winning their first two games, Tony Pulis' men have drawn two and lost one.
Man to watch out for: This will be a record-breaking game for Baggies midfielder Gareth Barry, as he is set to surpass Ryan Giggs as the highest appearance-maker in the history of the Premier League.
Prediction: Arsenal 3-1 West Bromwich Albion