Babe Ruth made his first career start on the mound on March 25, 1914 for the Boston Red Sox. The 19-year-old pitcher defeated the world champion Philadelphia Athletics, 6-2, in an exhibition game played in Wilmington, North Carolina. Prior to this game, Ruth had faced 29 batters in relief, allowing just six hits, thus earning his spot in the starting rotation.
Babe Ruth pitching (Bleacher Report)
