Lou Gehrig made the only pinch-hit appearance of his career on June 1, 1925 when he came off the bench to hit for infielder Pee-Wee Wanninger. While the common tale told is that Gehrig’s 2,130-game streak started when he replaced Wally Pipp at first base (held out of the line-up due to the aftereffects of a concussion), the first game of Gehrig’s streak actually came the day before, with this pinch-hit appearance.
The ALS Association Greater Philadelphia Chapter