The manufacturers of the most popular weight loss drugs are being challenged in court.
A federal court in Philadelphia will soon evaluate claims against the makers of Ozempic, Wegovy and similar products.
Dozens of patients who suffered gastrointestinal problems after taking these drugs brought lawsuits alleging that these companies failed to properly warn patients about the risks.
Over the past few years, celebrities and word of mouth made these drugs go viral on social media. More than 15 million Americans have reported using these drugs as of May 2024.
So, what do patients' claims about the risks associated with weight loss drugs mean for the future of these products? I'm a health law professor who studies pharmaceutical drug regulation and access to medicines, and I've been watching the legal developments closely. Regardless of how the trial turns out, I think it could have a big impact on public trust and on the market for weight loss drugs.
The drugs: Ozempic, Wegovy, Rybelsus, Trulicity and Mounjaro
Several types of medications fall under the umbrella of "weight loss drugs." The five drugs at stake in the lawsuit belong to the same class: GLP-1 agonists or analogs, short for glucagon-like peptide-1 receptor agonists. GLP-1 agonist drugs help manage blood sugar levels. They were originally approved for the treatment of Type 2 diabetes.
These drugs make people feel full. Doctors started prescribing them for weight management even before the FDA approved them for that purpose. This is a practice known as off-label prescribing. Off-label prescribing is legal and accounts for more than 20% of prescribing activity in the United States.
The companies: Eli Lilly and Novo Nordisk
The Danish company Novo Nordisk makes Ozempic, Wegovy and Rybelsus. The American company Eli Lilly makes Trulicity and Mounjaro.
Novo Nordisk has also made a mint on weight loss drugs. Its sales of Ozempic, Wegovy and Rybelsus have made it the most valuable company by market capitalization in Europe. It is currently more valuable than companies such as Tesla and Visa and has been described by one reporter as the " single company propping up " the entire Danish economy.
The lawsuit
On the medical side of things, the patients allege that these drugs increase the risk of gastrointestinal injuries. On the legal side, they allege that the companies failed to properly warn patients of the risks. The lawsuit also raises the question of whether the companies made incomplete or misleading representations about these drugs. The companies have signaled that they will challenge these claims.
The implications
We won't know the outcome of the case for a while. But this lawsuit will have immediate implications.
The lawsuit will likely remind people that no drug is free of risk and that patients need to be aware of these risks before and during treatment.
Second, while these drugs present risks, the FDA has reviewed the best available scientific evidence, performed a benefit-risk analysis and decided that the benefits are worth the risk.
For the past decade, however, the FDA's credibility has been under attack. Conspiracy theories about the agency abound on social media. The FDA is often the target of baseless accusations that it approves harmful drugs and suppresses good ones.
A major legal challenge to weight loss drugs could contribute to the ongoing erosion of trust in the FDA itself. And in an era of misinformation, conspiracy theorists could use the lawsuit to improperly suggest that these, or all, FDA-approved drugs are bad or unsafe.
While sales of weight loss drugs are currently stratospheric, sometimes a seemingly isolated event such as a lawsuit can set in motion cascading long-term effects.
Ana Santos Rutschman, Professor of Law, Villanova School of Law
This article is republished from The Conversation under a Creative Commons license. Read the original article.
