Cleveland, April 4th, 2016

MLB released its tentative 2016 schedule yesterday, and the Red Sox will open the season on the road (of course) against the Indians in Cleveland on April 4th. They will play three there, then play three in Toronto, and have their home opener against Baltimore on April 11th.
They will close the season at home against Toronto on October 2nd.
Looks like I'll be in San Diego on Labor Day, as the Red Sox will be there September 5-7.
Here's the complete schedule, with thanks to Allan at The Joy of Sox, who originally posted it. (Click to see the larger version):