The experiments by Folcher et al. are done with optogenetic implants in mouse brains that are wirelessly controlled by human brain waves. This is the proof of concept step, preliminary to trying the implants in humans to control the expression of engineered light sensitive regulators of genes for therapeutic proteins. Here is their cartoon summary of the procedure:
The mind-controlled transgene expression device consisted of (a) an EEG headset that captured brain-wave activities (the encephalogram), identified mental state-specific electrical patterns (biofeedback, concentration, meditation) and processed discrete meditation-meter values (0–100; meditation-meter value plot), which were transmitted via Bluetooth to (b) the Arduino single-board microcontroller with a time-relay device and switching the (c) field generator ON and OFF. This BCI (a–c) controlled (d) the TC (c,d) of the field generator, which inductively coupled with the (d,e) receiver coil (RC) of the (e) wireless-powered optogenetic implant. (e) The NIR light LED illuminated the culture chamber of the wireless-powered optogenetic implant and programmed the designer cells to produce SEAP, which diffused through the semi-permeable membrane. The blood SEAP (human secreted alkaline phosphatase) levels of mice with subcutaneous wireless-powered optogenetic implants containing designer cells that were freely moving on the field generator could be modulated by the human subject’s mindset in a wireless, remote-controlled manner.
