Resident Evil Requiem’s Complete Roadmap to All 49 Achievements

Last Updated on 9 March, 2026

Resident Evil Requiem has finally arrived to redefine survival horror, bringing players a terrifying new adventure featuring Leon Kennedy and FBI analyst Grace Ashcroft. Navigating the shifting perspectives and missable objectives across the Wrenwood Hotel and Raccoon City can easily overwhelm even the most seasoned zombie hunters. Our comprehensive roadmap solves this by providing a meticulous breakdown and optimized playthrough strategies to ensure you never miss a single crucial detail. From cracking safe codes to mastering combat, this guide offers everything you need to confidently conquer all forty nine achievements.

Did You Know? Game director Koshi Nakanishi initially hesitated to include Leon Kennedy because the character has seen so much that he no longer scares easily, making him a poor fit for a pure horror experience. This directly led to the creation of Grace Ashcroft, who is deliberately designed to be introverted and easily frightened to ground the horror.

Table of Contents

1. Difficulty Modes and Stacking
2. Special Run Completion Achievements
   • Never Touch the Stuff
   • Minimalist
   • Speed Demon
3. Chapter by Chapter Story and Missable Guide
   • Wrenwood City Streets (Leon)
   • Care Centre Main (Grace)
   • Care Centre Basement (Grace)
   • Water Treatment Plant (Grace)
   • Raccoon City East (Leon)
   • R.P.D (Leon)
   • Raccoon City Centre (Leon)
   • ARK Escape the Trash Compactor (Grace)
   • ARK Ending (Grace and Leon)
4. Combat Mastery Achievements
5. Crafting, Upgrades, and Economy
6. Collectibles and Safe Codes
   • Case Closed Notes
   • Mr. Raccoon Memoriam
   • No Safe is Safe Combinations

1. Difficulty Modes and Stacking

Resident Evil Requiem rewards players for tackling higher difficulties by automatically unlocking the achievements for the lower tiers. You have four main difficulty milestones to conquer.

1. Rookie Agent: Complete the main story on at least Casual difficulty. This option is available right from your first run. Completion unlocks the Rookie Agent achievement only.
2. Rising Agent: Complete the main story on at least Standard Modern difficulty. This option is also selectable from your first run. Completion unlocks both the Rising Agent and Rookie Agent achievements.
3. Resolute Agent: Complete the main story on at least Standard Classic difficulty. You can select this from the first run. Finishing this mode grants you the Resolute, Rising, and Rookie Agent achievements all at once.
4. Remarkable Agent: Complete the main story on Insanity difficulty. You must finish the game once on any difficulty to unlock the Insanity mode. Beating Insanity unlocks all Agent difficulty achievements simultaneously.

Pro Tip: Play through the game on any difficulty first to unlock Insanity mode. Once you beat the game on Insanity, the game automatically rewards you with all the lower Agent difficulty achievements at the exact same time.

2. Special Run Completion Achievements

You will need to plan specific playthroughs to tackle these three unique completion challenges.

Never Touch the Stuff

You must complete the entire main story without using any herbs or med injectors. Do not do drugs. Pressing the heal button by accident and overwriting your save file will completely ruin your progress. You will only realize you messed up when the achievement fails to unlock after beating the game.

Minimalist

This achievement requires you to complete the main story without allowing Grace to use the blood collector for crafting. Leon is free to craft whatever he wants. Picking up blood does not void the achievement. Only spending the blood in the crafting menu will fail the run. You can track your blood usage in the challenges list.

Speed Demon

You must complete the main story by releasing Elpis in under four hours. You need to run fast and avoid dying.

Pro Tip: Unbind your quick heal button immediately before attempting the Never Touch the Stuff run so you do not accidentally heal yourself. For your Minimalist and Speed Demon runs, unlock infinite ammo first to trivialize the challenge. You should also put the blood collector directly into an item box to get a free inventory square back. Furthermore, quit to the main menu and reload your last save if you die during your speedrun. Finally, avoid pairing the Minimalist achievement with a Classic or Insanity difficulty run because crafting ink ribbons requires blood.

3. Chapter by Chapter Story and Missable Guide

We have organized the story related and missable achievements by chapter. The game lacks formal chapter endings, so these divisions occur whenever the point of view shifts characters or the location changes significantly. Wrenwood Hotel, Rhodes Hill Care Centre Arrival, Care Centre Attic, Care Centre Courtyard, Care Centre Chapel, Raccoon City Orphanage Flashback, ARK Arrival, and ARK Lickers do not contain any specific achievements. Please note that while some achievements may be achievable in later chapters when you retrace your steps, we have not confirmed this, so your mileage may vary if you delay them.

Wrenwood City Streets (Leon)

• Déjà vu: You will encounter an outbreak in Wrenwood. This unlocks naturally at the end of the chapter.

Care Centre Main (Grace)

This chapter contains a massive amount of missable content.

1. Order Up!: Defeat the chef located in the kitchen. You must kill him before you jump down the hole to the basement. Are we sure he was even infected?
2. Deadly Duet: Defeat the two creepy vocalists. You will find one in the West Wing Bar and Lounge area and the other in the East Wing conference room. Kill them both before jumping down the hole.
3. Grace and Goliath: Defeat a Chunk enemy as Grace. You will encounter Chunk right before you collect the level 1 security pass. You can kill him easily with two to three Requiem shots or three haemolytic injectors.
4. Like Mother, Like Daughter: Unlock a drawer with a lockpick. You will find your first lockpick in the East Wing Lead Researchers Office. Take it and use it on the locked drawer in the East Wing Lobby on your way back out.
5. Science!: Unlock a crafting recipe using analysis. Process a blood specimen using the laser microscope. These items do not appear again after the care centre chapters.
6. Internal Dispute: Force a zombie to attack another zombie in the hospital wards. Enter the East Wing waiting room to find a black nurse zombie and a blind patient zombie. Throw empty bottles to lure the blind zombie toward the nurse until it lands an attack.
7. Descent Into Darkness: Reach the basement of the care centre. This unlocks automatically at the end of the segment.

Care Centre Basement (Grace)

1. Bring Out the Big Guns: Stun the Girl with Requiem. Load a Requiem shot and shoot her in the face.
2. It’s Been a Long Night: Reach the courtyard via the quartz lock door to unlock this story achievement.

Water Treatment Plant (Grace)

• A Harsh Reality: Escape the care centre to earn this story achievement at the end of the chapter.

Raccoon City East (Leon)

1. Crate Expectations: Open all BSAA containers before you open the gate with the detonator.
2. Road Rage: Stop Victor from attacking on the highway. Victor will eventually show up riding a bike while holding an RPG during the chase sequence. Unload your weapons into him as he prepares an attack.
3. Going Down?: Reach the ground using the suspended platform. This unlocks after you return to camp with the relay detonator part.

R.P.D (Leon)

• The Hero Returns: Arrive safely at the R.P.D. Welcome home.

Raccoon City Centre (Leon)

1. Not Today, Buds!: Defeat all the Plant 43 seedlings. After the short train journey, you will enter a chasm covered in hostile vines. Explore every side passage and kill all the attacking flower buds.
2. I Remember That, Too: Defeat the Super Tyrant. X gon give it to ya.
3. Umbrella’s Legacy: Find ARK at the end of the chapter.

ARK Escape the Trash Compactor (Grace)

• The Final Mission: Start exploring the lower levels of ARK. This unlocks as soon as Grace begins her segment.

ARK Ending (Grace and Leon)

• Hope and Requiem: Complete the main story by releasing Elpis. This is a choice dependant story achievement that unlocks as the credits roll.

Pro Tip: You must complete these missable achievements in the specific chapters listed. Even though you retrace some areas later in the game, delaying these tasks is incredibly risky because they might not be achievable upon your return.

4. Combat Mastery Achievements

You will unlock these achievements by mastering your weapons and taking down enemies with specific tactics.

1. Seasoned Pro: Defeat 300 enemies. You will naturally achieve this during a normal playthrough.
2. Can I Borrow This?: Throw a weapon dropped by an enemy. Shoot a weapon out of an enemy hand or kill them to drop it. Run to the weapon and press the button prompt to throw it at a surviving enemy.
3. Untouchable: Parry an enemy attack. The HUNK fight at ARK provides excellent parry opportunities.
4. Fatal Dose: Defeat a zombie using the haemolytic injector. Sneak behind a zombie while holding an injector and press the prompt.
5. Bang For Your Buck: Defeat at least three enemies with a single Requiem shot. Play as Grace in the Care Centre. Enter the corridor leading to the Lead Researchers Office stairs past the East Wing Waiting Room. Three zombies will attack you in a perfect line.
6. Chop Chop: Defeat three zombies with a hatchet finishing attack while playing as Leon.
7. Cat Got Your Tongue?: Cut the tongue off a Licker β2 using the hatchet. Aggravate a licker and keep parrying until it performs a lick attack.

Pro Tip: Kill zombies with the haemolytic injector to permanently prevent them from coming back as blister heads. Additionally, you should equip HUNK’s dropped hatchet, Mortal Edge, to widen your parry windows for the Untouchable and Cat Got Your Tongue achievements.

5. Crafting, Upgrades, and Economy

Resource management is critical for survival. These achievements track your item creation and spending habits.

1. The Ol’ Fashioned Way: Use an ink ribbon to save at a typewriter on Standard Classic or Insanity difficulty. You will find the first typewriter and ink ribbon in Grace’s Chapter 3 inside Room 201 behind the Cherub Door.
2. Out of Sight, Out of Mind: Store an item in the item box as Grace. You will find item boxes next to save points.
3. The Power of Blood: Craft an item using the blood collector. Acquire the collector in the Care Centre East Wing blood lab. Gather blood from enemies or buckets to craft items.
4. Blood! More Blood!: Use 300 microsamples of infected blood.
5. Bloodlust: Collect 5000 microsamples of infected blood.
6. Master Craftsman: Craft every possible item with Leon. You must craft exactly nine items. This includes four ammo types, two grenades, and three herb mixtures.
7. Retail Therapy: Purchase an item from the supply box. Take Leon to the item box in Raccoon City East and buy something with credits earned from killing zombies and turning in locator tags.
8. Tailor Made: Upgrade a weapon at the item box in Raccoon City East.
9. Credit Where Credit Is Due: Earn 200,000 credits. This achievement tracks your total across multiple playthroughs. You will likely unlock it on a second playthrough.
10. Curator and Model Mania: View all concept art and models. You need to beat the game and save up 5600 points for the art and 4400 points for the models in the Bonuses menu.

Pro Tip: Prioritize buying infinite ammo and weapon modifiers over art to speed up later runs. Craft every green herb mixture iteration to secure the Master Craftsman achievement. Lastly, use blood bags to accelerate your Bloodlust achievement progress.

6. Collectibles and Safe Codes

Scour the environment to find every hidden secret to wrap up your achievement list.

Case Closed Notes

You must read all 75 files scattered throughout the main story. Here is a list of the areas and their totals:

1. Wrenwood: 6 Notes
2. Rhodes Hill: 41 Notes
3. Raccoon City: 18 Notes
4. ARK: 10 Notes

For the visual learners, here’s a YouTube video to help you out with precision finding of all the 75 Files above.

Mr. Raccoon Memoriam

Destroying one statue unlocks The Hunt Begins. Destroying all 25 unlocks You Little Rascal!. Here is a list of the areas and their totals:

1. Wrenwood: 0 Statues
2. Rhodes Hill: 10 Statues
3. Raccoon City: 13 Statues
4. ARK: 2 Statues

For the visual learners, here’s a YouTube video to help you out with precision finding of all the 25 statues above.

No Safe is Safe Combinations

You must open all five safes in the main story. The combinations change depending on your difficulty level.

Safe Location Casual and Standard Code Insanity Code

Care Centre Exam Room R30 L10 R50 L50 R30 L90

Care Centre Bar and Lounge L10 R80 L30 R20 L50 R30

Care Centre Basement R60 L40 R80 L70 R50 L20

ARK Sterilisation Lab R10 L90 R20 L80 R50 L0

ARK Monitor Control Room L50 R60 L80 R20 L0 R70

Pro Tip: Always double check your selected difficulty level before trying to open a safe. The game completely changes the safe combinations when you step up to the Insanity difficulty tier.

Conclusion

Securing every achievement in Resident Evil Requiem serves as the ultimate testament to your survival horror mastery and unyielding dedication. This guide has equipped you with the exact strategies needed to conquer Insanity difficulty and solve the most obscure puzzles the game throws your way. By carefully managing your saves and utilizing our targeted combat tips, you can efficiently wrap up your remaining collectibles and special speedrun challenges. Now it is time to confidently step back into the terrifying world crafted by Capcom and claim your hard earned completion status.

Fun Fact: The PC release shattered previous franchise records by reaching a peak of 344,214 concurrent players on Steam during its launch weekend. For comparison, that is more than double the peak player count of the Resident Evil 4 Remake.