In a tweet posted on Tuesday, Nadal said: "I have decided not to play at this year's US Open. The situation is very complicated in the world, cases of COVID-19 are on the increase, it seems that we still don't have control of it. "
More than 155,000 Americans are known to have died from the virus, and the death toll is expected to reach 173,000 by August 22, according to a new composite forecast from the United States Centers for Disease Control and Prevention.
World No.2 Nadal is a four-time US Open winner and has collected 19 Grand Slam singles titles, one behind Roger Federer, who will also miss the US Open with a knee injury.
The USTA announced on Tuesday that world No.1 Novak Djokovic has entered the men's singles peloton for the 2020 Open, scheduled for August 31 to September 13 in New York City.
However, players on the entry list will not necessarily compete in the US Open, as many players have yet to make the final decision on whether or not to play.

On the entry list with Djokovic, three-time US Open champion, six other men from the top 10 world, including Dominic Thiem and Daniil Medvedev, US Open finalist in 2019.
On the women's side, world No. 1 Ashleigh Barty has already announced that she will not play at the US Open.
Defending champion Bianca Andreescu is among the women, with world No.2 Simona Halep - two-time Grand Slam champion - as well as six-time US Open winner Serena Williams and Naomi Osaka, 2018 New Tournament winner. York.
