Mapping neurotransmitter systems to the structural and functional organization of the human neocortex | https://t.co/CLp1wYHP35
— Bratislav Misic (@misicbata) October 27, 2022
Led by @JustineYHansen out now in @NatureNeuro!
TLDR: we curate an atlas of neurotransmitter receptors and relate it to brain organization 🧩🧠🌎⤵️ pic.twitter.com/XB6swrVv78
Abstract of the linked article:
Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncovered a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we found both expected and novel associations between receptor distributions and cortical abnormality patterns across 13 disorders. We replicated all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.
This is relevant to the concept of behavioral mode as set-forth in Principles and Development of Natural Intelligence.
Tweetstream presenting the findings:
2⃣ We make this data available!
— Bratislav Misic (@misicbata) October 27, 2022
Data + code: https://t.co/pXYtm2djCx
Also available on neuromaps (https://t.co/YhSmgWiyiz)https://t.co/woRpIq4bWL
4⃣ Using diffusion weighted MRI and functional MRI, we show that neurotransmitter receptor profiles are systematically aligned with structural and functional connectomes and follow common organizational principles.
— Bratislav Misic (@misicbata) October 27, 2022
Cool part: receptors enhance prediction of FC from SC! 😎 pic.twitter.com/u06NdN2wjV
6⃣ Using the @neurosynth meta-analytic cognitive atlas, we uncover a topographic gradient of receptor profiles that links monoamine receptors with affective processing. pic.twitter.com/hkN5DHD0iQ
— Bratislav Misic (@misicbata) October 27, 2022
8⃣ Then we do it all again in an independently collected autoradiography dataset and across multiple methodological choices (tracer choices, parcellations, etc.) pic.twitter.com/hkV9596UWY
— Bratislav Misic (@misicbata) October 27, 2022
🔟Thanks to all our collaborators including the many researchers that shared their PET data with us! ✨💪🚀
— Bratislav Misic (@misicbata) October 27, 2022
Also massive thanks @amykooz Trevor Robbins @sattertt @valerieJsydnor & Sachin Ranade for their input and guidance!
