Genotype-phenotype Maps and Mathy BiologyPosted on the 28 September 2012 by Bjornostman @CarnyEvolution
I love it. But just before this figure he has this equation:
I hate it. I hate it because all it says is that each type, x, is at a frequency P of the total population, so those Px sum to one. But of course. I just don't think this kind of writing is conducive to discourse, because in biology there is already a huge gap between the majority who don't read (and cite) papers with equations, and those who write them. So why muddy the waters with equations like this that says next to nothing?
However, I reiterate (and is why I'm reading the chapter) that this figure of a genotype-phenotype-fitness map is super cool.There are many more different genotypes (the genetic make-up of an organism) than there are different phenotypes (the combined physical attributes of the organism). This must be so, because we now know that each trait is affected by many genes; it takes more than one gene to make a trait (there may be exceptions where only one gene encodes a trait).
The figure is a conceptual map, but real g-p mapping is sort of the holy grail in evolutionary biology at the moment. With a real map like in hand evolutionary dynamics can be predicted, and we will be able to say which genetic changes are required to change the phenotype. However, realistically we can only map a very small portion of the genotype on to the phenotype, and there even seems to be some confusion about what the proper answer is to the question of what the genotype-phenotype map looks like. Hopefully the answer won't be too mathy...
 Peter F. Stadler and Christopher R. Stephens (2003). Landscapes and Effective Fitness Comm. Theor. Biol, submitted to, 2003. Santa Fe Insitute Working Paper: 0210048. DOI: 10.1080/08948550302439
 A testable genotype-phenotype map: Modeling evolution of RNA molecules. In: Lässig, M. and Valleriani, A., editors, Biological Evolution and Statistical Physics, pp. 56–83. Springer-Verlag, Berlin, 2002.
These articles might interest you :
After getting off the phone with a friend, you suddenly feel a headache coming on. You are absolutely drained and have nothing left, so you go to eat food... Read moreBy Drowqueen
The mailbox mobile app has officially announced its retirement. Once an extremely popular mobile email client Mailbox will no longer be seen on Android iOS... Read moreBy Gaurav Tiwari
#PHlovesBanilaCo Korean cosmetics are one of the reasons why I started blogging. My love for K-dramas greatly influences my love for Korean makeups. Read moreBy Berrycreamie
Maybe I’ve had a couple of glasses of champagne; maybe I’ve enjoyed tonight’s meal just a little too much and I am now feeling sated and content; maybe my... Read moreBy Bradshaw
There is sad news for the outdoor adventure community today as it was announced last night that Doug Tompkins, the founder of The North Face, has passed away... Read moreBy Kungfujedi
On Today’s Show:This week…Joe’s big move was full of surprises. Plus, Scott Weiland debuts on the underground scene. And Al Roker can’t catch a cab. Read moreBy Christopher De Voss
If the weather were a person right now, it would be an awkward adolescent. Braces, glasses… the whole shabang. Awkward. My kids were in shorts yesterday and... Read more4 hours, 47 minutes ago by Samantha Curtis
DIARIES, FAMILY, SELF EXPRESSION
MOST RECOMMENDED IN BIOLOGY
- Can human evolution kill creationism? by Reprieve
- Humans could have driven Neanderthals extinct, even if they were as smart as us by Reprieve
- Was prehistoric tool use in the genes? by Reprieve
- Nature Night 2016 by Iratemonkey