Genotype-phenotype Maps and Mathy BiologyPosted on the 28 September 2012 by Bjornostman
I love it. But just before this figure he has this equation:
I hate it. I hate it because all it says is that each type, x, is at a frequency P of the total population, so those Px sum to one. But of course. I just don't think this kind of writing is conducive to discourse, because in biology there is already a huge gap between the majority who don't read (and cite) papers with equations, and those who write them. So why muddy the waters with equations like this that says next to nothing?
However, I reiterate (and is why I'm reading the chapter) that this figure of a genotype-phenotype-fitness map is super cool.There are many more different genotypes (the genetic make-up of an organism) than there are different phenotypes (the combined physical attributes of the organism). This must be so, because we now know that each trait is affected by many genes; it takes more than one gene to make a trait (there may be exceptions where only one gene encodes a trait).
The figure is a conceptual map, but real g-p mapping is sort of the holy grail in evolutionary biology at the moment. With a real map like in hand evolutionary dynamics can be predicted, and we will be able to say which genetic changes are required to change the phenotype. However, realistically we can only map a very small portion of the genotype on to the phenotype, and there even seems to be some confusion about what the proper answer is to the question of what the genotype-phenotype map looks like. Hopefully the answer won't be too mathy...
 Peter F. Stadler and Christopher R. Stephens (2003). Landscapes and Effective Fitness Comm. Theor. Biol, submitted to, 2003. Santa Fe Insitute Working Paper: 0210048. DOI: 10.1080/08948550302439
 A testable genotype-phenotype map: Modeling evolution of RNA molecules. In: Lässig, M. and Valleriani, A., editors, Biological Evolution and Statistical Physics, pp. 56–83. Springer-Verlag, Berlin, 2002.
These articles might interest you :
female athletes deserve recognition Female professional athletes in this nation do not get the recognition they deserve. As a female athlete who competes at... Read moreThe 06 April 2015 by Juliez
SOCIETY, WOMEN'S ISSUES
More than quarter of the world’s population suffers from high cholesterol. Cholesterol is present in every cell of our body and is essential for its functioning. Read moreThe 06 April 2015 by Health_news
The Tripurantakeswara Swamy Temple, ThiruvirkoovamThe name Cooum to any Chennai dweller would be synonymous with a nauseating cesspool where all the water... Read moreThe 06 April 2015 by Priyabaskar
The best way of experiencing something authentic is to actually travel to a place where that thing originated; you can’t get more genuine than that. But in the... Read moreThe 06 April 2015 by Adrenaline Romance
Dot Webstie hits the 50,000 registration mark Radix released some stats about one of their strings today, Dot Website went over 50,000 regs, they did actually... Read moreThe 06 April 2015 by Worldwide