The New York Highlanders (later known as the Yankees) played their first game in as a New York City team on April 22, 1903. The Highlanders lost their opener to Washington, 3-1, at Hilltop Park in front of 11,950 fans. Pitcher Jack Chesbro took the loss, but he would finish the season with a 21-15 record (.583) and an ERA of 2.77.
Hilltop Park (Wikipedia)