I'm reading the opening of a novel (that shall remain nameless) and I hate everyone in it. Well, except for one minor (so far) character to whom I am pretty much indifferent. And there are situations (non sexual) that make me want to go take a bath -- and remember, I live on a farm where manure and chicken butchering are facts of life.
I have finished some books that creeped me out -- and then wished that I could forget them, I have finished others, in spite of the animal abuse, or whatever, and felt that I learned something valuable -- but that I would never read that book again. (And mostly, if I really like a book, I do re-read.) The play "Death of a Salesman" is one that I read and recognized as powerful and moving -- so much so that I would never choose to go see it.
As I said, the problem with this particular story is a bunch of unlikable characters and a pathetic/semi-crazy protagonist. I'm waiting for some redeeming qualities in the unlikable characters and some way of understanding or connecting with the main character.
A more or less standard rule of writing fiction is to have a main character that people like or identify with or somehow feel connected to -- so that the reader feels invested in finding out what happens to that main character. (An exception to this -- and of course there are exceptions, would be Ron Rash's Serena -- the title character is so staggeringly evil that the reader may well be hypnotized, like a deer in the headlights, into staying with the story. And Rash's beautiful writing doesn't hurt.)