The American Heart Assn. calls them "game changers."
Oprah Winfrey says they're "a gift."
Science magazine anointed them the " 2023 Breakthrough of the Year."
Americans are most familiar with their brand names: Ozempic, Wegovy, Mounjaro, Zepbound. They are the medications that have revolutionized weight loss and raised the possibility of reversing the country's obesity crisis.