I tested it out on a few of our business Twitter accounts. At first I liked it and then it go to be too much work weeding out those that made no sense to follow - like those that spoke difference languages. And then they were tweeps that had nothing to do with our niche, never engaged in conversations or followed back.
If you have a new Twitter account and not a lot of time it may be worth it. We had a new one for a line of specialty medical scrubs that we used it for. It did generate followers more quickly than doing it on your own. I would recommend Tweet Big where you can use up to 3 Twitter accounts. And they offer a Free trial of one week to test it out.
When you have a particular niche I believe you should stick to the topics and interests of that niche. It will give you a tighter community in the network and higher engagement. If you just follow everyone it will become a little overwhelming. If you can stick with your niche on Twitter you will thrive there.
I've just started on Google+ and am working on the follow strategy. On Google+ it's called Circles. You can have circles like friends, acquaintances, co-workers, etc. You can decide where to put people and when you share - you can decide with whom to share with. I may for example not share my family photos with anyone but family. And if you don't really want anyone to see something - I would not share at all.
Facebook on the other hand is different. It's more social, a lighter personality and more personal. On Facebook you know people, on Twitter and other social networks you get to know people. Would you agree?