The looming sequester will make virtually all of Obama's second-term legislative agenda, including a few items that have Republican support, essentially dead on arrival.
Take immigration reform:. With the Republican Party looking for new ways to reach out to Hispanic voters, it appears to have a good chance of passing. But many conservatives insist that they will only support a comprehensive reform bill if it makes securing the border a precondition of giving illegal immigrants a path to citizenship. But the sequester would require a cut in border guard numbers. More here