Here are best answers to some questions I recently received. Please email questions as it is hard to respond this way
Please explain if CD 19 is present on both the normal B Cell and cancerous B cell as stated here, then how can CD 5, CD 19, and CD23 be what is used to diagnose CCL per Dr. Weird in a Patient Power interview? Also, are any of the 3 CD’s mentioned above also present in T Cells? on ASH 2012: Dr. Bill Wierda on CAR-T Therapies and "Off the Shelf" T-Cells
ANSWER: CD5 is usually only found on T cells. Its presence on monoclonal B cells helps diagnose CLL
Hello Dr. Kauffman, I am four years out from a CLL stem cell transplant. I wondering how long ones immune system is compromised after a transplant? Would I still catch pneumonia really easy? on Dr. Byrd Updating the trial data on ibrutinib for CLL (Chronic lymphocytic Leukemia)
ANSWER: Immune recovery post transplant is slow and complicated. Suffice it to say, one remains at increased infection and cancer risk for years after, but after about 2 years, most of the high risk period is behind you.
on 10/10/15
In looking at the ASCO abstract, information is not provided as to the cause of treatment interruption. An interruption due to a drug complication or cll event may have a very different impact on PFS than a break in care for surgery. Is that data available? ANSWER: I understand that many of the patients were quite sick for multiple reasons and that's why they quit.