Cake of Cure
OK team, we have taken the first giant step in this moon shot. We've safely landed in a new world of disease control with no chemo. Now get us home.
The real work is just beginning.
We need potent combos of these new wonder drugs to help us stay in the land of remission forever, get off the daily meds, and maybe, just maybe find our decades from now that we have been cured.
We need more trials, trials that use NO chemotherapy. Trials that use drugs from different pharmaceutical companies. Abbvie links with Infinity Pharmacyclics is already working with TG Therapeutics in a clinical trialWe need more of these alliances that break down commercial barriers for the benefit of the patients.
We need brave patients to volunteer. While all of this sound so positive, let's not forget that when Gilead ran a sensible and necessary trial combining its Syk inhibitor, GS-9973 and its better known PI3k inhibitor, idelalisib or Zydelig (click here for the abstract), they concluded: "Despite promising activity in CLL, the combination of GS-9973 and Idelalisib resulted in an unexpectedly high rate of pneumonitis and resulted in stopping dosing of the combination These data need to be considered when designing future investigations combining inhibitors of B cell receptor signaling"
So we can't take anything for granted. These trials need to be carefully designed and monitored. But they are our best path to a cure.
It demands patients and providers and industry and the FDA all fighting together to "bake a cake of cure" for CLL.
I like it.
Please enjoy this upbeat and realistic one minute video of my doctor, Dr. John Byrd out of OSU.
More soon on ROR1 including an exciting new trial, and also on challenging paper on new mathematical modeling of ibrutinib resistance.
Good times indeed. Let's have our cake (vegan of course) and eat it.If you want a personal response, or just want to stay in touch, please email me at bkoffmanMD@gmail.com. I have no other way of contacting. Thanks. Stay strong. After all, we are all in this together.