Watching how this guys leads off third base is an
important job for any third baseman.
At the higher levels, I can remember catching instructors telling the catchers that if runners' shoulders are squared up to them they should do the following: catch the pitch and throw it right at the runner's head. The logic is that when the runner is facing the catcher and the ball is thrown at their head, the runner is in a horrible position to return to the bag. He more likely is going to react to the throw by just getting out of the way so as not to get hit. He's also more likely to be out. Of course, the third baseman needs to be aware that the throw is going to be made so he can be at the bag in time.
A snap pick-off throw to third base may only be successful once or twice a season. This is why third basemen need to be aware of what is going on around them and not be afraid to put on a pick off play after the pitch. They must be able to take advantage of the runner's mistake before a coach can tell him to watch out. If he waits too long, the opportunity is lost.